Targeting biofilms using phages and their enzymes

The complex biofilm architecture composed of extracellular polymeric structures (EPS) provides a protective shield to physiologically diverse bacterial cells immersed in its structure. evolutionary interplay between bacteria and their viruses (phages) forced the latter ones develop specific strategies overcome defensive barriers kill sessile cells. Phages are equipped with wide panel enzyme-degrading EPS macromolecules which together powerful weapons combat biofilms. Antibiofilm performance can be achieved by combining phages or phage-borne enzymes other antimicrobials such as antibiotics. Nevertheless, variety encoded phage genomes still need explored. To advance control we must deepen understanding biology itself, well discover better exploit unlimited antibacterial potential phages.